Pathergic Granulomatosis

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Abstract
An editorial in a recent issue ofThe American Journal of Medicineproposed the diagnosis of "pathergic granulomatosis" for a group of conditions characterized by necrotizing granulomata and angiitis and involving multiple tissues or single organs. The author, Robert Fienberg,1considered Wegener's granulomatosis as an example of disseminated pathergic granulomatosis and suggested that idiopneumonic granulomatosis, pneumonitis of the cholesterol type, eosinophilic granuloma of the lung, and Cogan's syndrome are examples of the focal type. The purpose of this article is to report two cases which we believe are instances of pathergic granulomatosis, one disseminated and the other focal. The disseminated case fulfills the clinical and pathologic criteria associated with Wegener's granulomatosis. The focal case was diagnosed as malignant granuloma of the face, but we believe it may be an additional example of a focal pathergic granulomatosis not mentioned by Fienberg. This report also includes a

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