FORMATION AND URINARY-EXCRETION OF CYPROHEPTADINE GLUCURONIDE IN MONKEYS, CHIMPANZEES, AND HUMANS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 8  (6) , 422-424
Abstract
Cyproheptadine is an antihistamine-antiserotonin agent. The urinary excretion of cyproheptadine glucuronide (a quaternary ammonium glucuronide) was studied in monkeys, chimpanzees and humans after a single 5 mg oral dose of cyproheptadine. Humans and chimpanzees excreted, over a 48 h period, an average 12.4 and 8.6% of the dose, respectively, as cyproheptadine glucuronide. Various species of monkeys excreted < 0.5% of the dose as the quarternary ammonium glucuronide conjugate. The unusual drug metabolites are excreted in the urine in relatively large amounts only in higher primates.

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