The bioavailability for four different commercially available brands of ampicillin compared with that of talampicillin

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Abstract
A five-way crossover study in 10 volunteers was carried out to determine the bioavailability by the oral route of 4 brands of ampicillin and of talampicillin. There were no significant differences between the 4 ampicillins in terms of maximum serum levels, times of peak levels, serum concentrations at each sampling time, area-under-curves, half-lives and percentage urinary excretion (including peniciloate). A significantly higher proportion of the dose of ampicillin (65.6%) appeared in the urine after giving talampicillin than after giving any of the ampicillins (mean value = 38%). Thus, while there is no bioinequivalence amongst these ampicillin brands, talampicillin is a more effective way of delivering ampicillin. There were some indications that females absorb ampicillin less well than do males, and that there may be ‘good’ and ‘bad’ absorbers of ampicillin.

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