Smooth Muscle Relaxing Flavonoids and Terpenoids fromConyza filaginoides*

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Abstract
Activity-guided fractionation of the smooth muscle relaxing, chloroform-methanol (1:1) extract of Conyza filaginoides (D.C.) Hieron (Asteraceae) led to the isolation of three flavonoids (quercetin 3-glucoside, rutin, and pinostrobin), one sterol (α-spi-nasterol), a sesquiterpenoid (β-caryophyllene 4,5-α-oxide), and two triterpenoids (erythrodiol and 3-β-tridecanoyloxy-28-hydroxyolean-12-ene). 3-β-Tridecanoyloxy-28-hydroxy-olean-12-ene is a new naturally occurring terpenoid. All the isolated compounds induced a concentration-dependent inhibition of the spontaneous contractions of rat ileum. The spasmolytic activity exhibited by the extract and active principles tends to support the traditional use of C. filaginoides as an antispasmodic agent.

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