Disseminated intravascular coagulation in rabbits: synergistic activity of meningococcal endotoxin and materials egested from leucocytes containing meningococci (Plates XXVII and XXVIII)
Leukocyte-egested material was harvested after the quantitative in-vitro phagocytosis of Neisseria meningitidis by rabbit or mouse polymorphonuclear leukocytes. The egested material was injected s.c. into rabbits and followed 24 h later with an i.v. injection of a non-lethal quantity of meingococcal endotoxin, or with an equivalent dose of endotoxin in the form of meningococcal cell-wall blebs. Of 32 rabbits treated in this manner, 12 developed disseminated intravascular coagulation and six of these 12 had renal cortical necrosis. The remainder exhibited less severe lesions resembling those of endotoxemia. Rabbits were not sensitized to meningococcal endotoxin when materials egested from leukocytes containing Staphylococcus epidermidis were used. A description of the pathological findings in the rabbits is presented.