THE METABOLISM OF 1-DEHYDRO-17-HYDROXYCORTICOSTEROIDS IN HUMAN SUBJECTS

Publisher Website
Google Scholar
Abstract
EVEN though the l-dehydro-17-hydroxycorticosteroids (Δ1-17-OHCS) have been in clinical use for some time and have proved to be effective in much smaller doses than the 17-hydroxycorticosteroids (cortisone, cortisol), only one brief article (1) has appeared concerning their metabolism in human subjects. In this paper we wish to present studies on the metabolism of 1-dehydrocortisol (Δ1-F) and 1-dehydrocortisone (Δ1-E) in man, with particular emphasis on the differences observed when compared with the metabolism of cortisone and cortisol.1 The metabolism of 4-C14-1-dehydrocortisol will be the subject of a separate report. METHODS Patients of botli sexes between the ages of 7 and 66 years were hospitalized on the Metabolic Ward and given steroids by oral ingestion (10–240 mg. per day) or by intravenous injection (1 mg. per Kg. body weight). The oral steroids were given in tablet form as prednisone (Aleticorten) or prednisolone (Meticortelone). The intravenous steroids were injected either as the hemisuccinates dissolved in small amounts, of an aqueous solution, or as the free alcohols in a 5 per cent ethanol solution. The levels of unconjugated 17-hydroxycorticosteroids2 (17-OHCS) in the plasma were determined by the method of Nelson and Samuels (3). Urines were collected with preservative (toluene) and analyzed for 17-OHCS by the method of Glenn and Nelson (4) and for 17-ketosteroids (17-KS) by the method of Klendshoj et al. (5), using the Allen correction as demonstrated by Chang and Slaunwhite (6).

This publication has 0 references indexed in Scilit: