BRAIN REACTIVITY OF LYMPHOCYTOTOXIC ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS WITH AND WITHOUT CEREBRAL INVOLVEMENT
- 1 January 1977
- journal article
- research article
- Vol. 30 (3) , 333-337
Abstract
A prospective clinical study of cold-reactive lymphocytotoxic antibodies in systemic lupus erythematosus was completed. A highly significant association between serum lymphocytotoxicity and the development of cerebral manifestations was observed. Lymphocytotoxic antibodies from patients with cerebral lupus were absorbed by homogenates of human brain; those from patients who at no time had evidence of cerebral disease failed to cross-react with brain. Subpopulations of lymphocytotoxic antibodies may differ in their brain reactivity. One population may be causally related to the development of some of the features of cerebral lupus.This publication has 15 references indexed in Scilit:
- SYSTEMIC LUPUS-ERYTHEMATOSUS - REVIEW OF 110 CASES WITH REFERENCE TO NEPHRITIS, NERVOUS-SYSTEM, INFECTIONS, ASEPTIC NECROSIS AND PROGNOSIS1977
- Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.Journal of Clinical Investigation, 1976
- Nature of cold‐reactive antibodies to lymphocyte surface determinants in systemic lupus erythematosusArthritis & Rheumatism, 1975
- Duration and death in systemic lupus erythematosus. An analysis of 249 cases.1974
- Immunofluorescence Studies on Thymocytotoxic Antibody from New Zealand Black MiceThe Journal of Immunology, 1974
- The Fourth Component of Complement in the Cerebrospinal Fluid in Systemic Lupus ErythematosusArthritis & Rheumatism, 1973
- Natural cytotoxic autoantibody against thymocytes in NZB mice.1972
- The Choroid Plexus in Systemic Lupus ErythematosusAnnals of Internal Medicine, 1972
- Brain-associated Θ antigen: Reactivity of rabbit anti-mouse brain with mouse lymphoid cellsCellular Immunology, 1971
- THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUESThe Journal of Experimental Medicine, 1964