Organization and evolution of the rat tyrosine hydroxylase gene
- 1 August 1987
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 26 (16) , 5208-5212
- https://doi.org/10.1021/bi00390a046
Abstract
This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out of 12 intron/exon boundaries are identical for the two genes. These results support the idea tha these hydroxylase genes are members of a gene family which has a common evolutionary origin. We predict that this ancestral gene would hav encoded exons similar, to those of TH prior to evolutionary drift to other members of this gene family.Keywords
This publication has 11 references indexed in Scilit:
- Molecular structure and polymorphic map of the human phenylalanine hydroxylase geneBiochemistry, 1986
- Sequence homology between tyrosine hydroxylase mRNA and a rat adrenal medullary cDNAJournal of Neuroscience Research, 1985
- Complete coding sequence of rat tyrosine hydroxylase mRNA.Proceedings of the National Academy of Sciences, 1985
- Intron/exon structure of the chicken pyruvate kinase geneCell, 1985
- Structure of the two related elastase genes expressed in the rat pancreas.Journal of Biological Chemistry, 1984
- Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencingGene, 1984
- Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase mRNA.Journal of Biological Chemistry, 1983
- The rat serum albumin gene: analysis of cloned sequences.Proceedings of the National Academy of Sciences, 1979
- The isolation of structural genes from libraries of eucaryotic DNACell, 1978
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977