DURATION OF RENAL ISCHEMIA REQUIRED TO PRODUCE UREMIA

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Abstract
Dogs with the right kidney removed uniformly survived clamping of the left renal artery for 2 hours. Some dogs survived clamping of the renal artery for 3 or 4 hours. Death in uremia regularly ensued with longer clamping of the renal artery. In dogs subjected to 3 hr. of renal ischemia the mortality was greater during summer, with high environmental temp. and humidity, than during winter, with low temp. and humidity. After the clamp was removed from the renal artery, the urea clearance was extremely low, of the order of 1-10% of normal, and blood urea began to rise rapidly. If recovery ensued, a steady rise of renal function occurred as measured by the urea clearance, and the clearance eventually reached a normal level, although a mo. was sometimes required for it to do so. If recovery did not take place, renal function remained at a low level, with progressive rise in blood urea N terminating in uremia and death.

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