Synthetic Studies toward Potent Cytotoxic Agent Amphidinolide B : Synthesis of the Entire C14-C26 Moiety of the Top Half
- 1 June 1997
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 26 (6) , 563-564
- https://doi.org/10.1246/cl.1997.563
Abstract
Regioselective hydroboration of a 4-methyl-2-alkene, oxidation of the resulting mixture of isomeric alcohols, and finally diastereoselective reduction of the ketone are the key steps in the stereoselective synthesis of C19-C26 fragment of amphidinolide B which was coupled with the C14-C18 fragment leading to the first synthesis of the entire C14-C26 moiety of this important molecule.Keywords
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