Local recurrence and survival in soft-tissue sarcomas

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Abstract
Background: There is a continuous interest in the literature concerning the management and survival after treatment of local recurrence in sarcomas because it is one of the most common types of recurrence. Design: We retrospectively reviewed 93 patients treated for local recurrence from soft-tissue sarcoma. Methods: We evaluated prognostic parameters (grade, tumor size, location) and the effect of treatment on survival. Results: Resection of all the gross tumor at first visit to our Institute for local recurrence was accomplished in 88 patients (95%). Of the 59 patients with extremity tumors, six (10%) required an amputation. At a mean follow-up of 66 months, further local recurrence was noted in 27%. The estimated 5-year survival rate was 100% for patients with grade I tumors (n=16), 77% for grade II (n=31), and 45% for grade III tumors (n=46) (p=0.0002). This value was 78% for tumors ≤5 cm and 57% for those >5 cm (p=0.03). Conclusions: Local recurrence is resectable and limb preservation is possible in the majority of patients. The overall 5-year survival rate was 65%. Survival after treatment of local recurrence is determined mainly by the grade and secondarily by the size of the tumor as for primary sarcomas.

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