Non‐seminoma Germ Cell Tumours (Malignant Teratoma) of the Testis Results of Treatment and an Analysis of Prognostc Factors*

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Abstract
The results of treatment of 126 patients with non-seminoma germ cell tumors (malignant teratoma) of the testis are presented. Of this group 81% are alive and 70% disease-free. Of 98 patients who had no prior treatment, 83% are alive and 76.5% disease-free. Of 43 early-stage patients, 41 (95%) are alive and tumor-free despite a 21% relapse rate after radiotherapy. The disease-free rate in patients with advanced disease treated with chemotherapy, and in some cases radiotherapy and/or surgery, ranged from 100-9% and was strongly dependent upon the volume of metastatic tumor and the histology. Patients with malignant teratoma undifferentiated (embryonal carcinoma) showed a significantly higher disease-free survival rate than those with malignant teratoma intermediate (teratocarcinoma). Twenty-six men with advanced disease received radiotherapy after chemotherapy; of these, 23 (88%) are alive and 21 (81%) are disease-free. No difference in disease-free survival rate was seen between advanced-stage patients receiving vinblastine and bleomycin and those receiving, in addition, cis-platinum. The overall drug-related mortality was 4.5%. Serum .alpha.-fetoprotein (AFP) and .beta.-human chorionic gonadotropin (.beta.-HCG) levels were valuable monitors in advanced disease but not prognostically significant if allowance was made for tumor volume. Fifteen patients had surgical resection of residual masses; 1 died post-operatively.