Interpretation of Rodent Hepatocellular Proliferative Alterations and Hepatocellular Tumors in Chemical Safety Assessment,
Open Access
- 1 February 1982
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 10 (2) , 71-78
- https://doi.org/10.1177/019262338201000210
Abstract
Benign and malignant liver tumors have been frequently observed in National Cancer Institute/National Toxicology Program rodent carcinogenesis bioassays using Fischer 344 rats and B6C3F1 mice. A multilayered pathology review process enhances consistency and accuracy of the histologic diagnoses. All data, including statistically analyzed tumor prevalences, are ultimately reviewed by a multidisciplinary team of scientists for judgment regarding the carcinogenicity of the chemical. Rationale for interpretation of hepatocellular alterations is illustrated with results from the recently completed NCI/NTP bioassays of di(2-ethylhexyl)phthalate, C.I. Disperse Yellow 3, C.I. Solvent Yellow 14, and pentachloroethane.Keywords
This publication has 1 reference indexed in Scilit:
- Carcinogenesis bioassay results from the National Toxicology Program.Environmental Health Perspectives, 1982