Lymphocyte-Mediated Cytolysis and Disease

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Abstract
Lymphocytes are equipped to eradicate noxious agents (microbes, cancer cells, and grafts) that disturb the body's equilibrium, but when their cellular activity is excessive, the results are harmful. The list of abnormalities known to be caused by excessive lymphocyte activity is extensive. We review two distinct pathways that account for most of the cellular injury induced by lymphocytes, with an emphasis on their clinical implications.The Molecular Basis of Lymphocyte-Mediated CytolysisUnlike humoral immune responses, which are mediated through antibodies and complement and can be transferred in serum to unimmunized subjects, cellular immune responses require the direct participation of effector . . .