The Wiskott-Aldrich Syndrome

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Abstract
The immunologic status of a 23 year old male with the Wiskott-Aldrich syndrome was evaluated. Immunoglobulin G [IgG] and IgM were normal, IgA was elevated. His anti-streptolysin and anti-staphylococcal titers showed a normal rise following infection with these organisms. In contrast a defect was demonstrated in the thymic dependent small lymphocytes. This was shown by long term tissue culture studies with phytohemagglu-tinin. The lymphocytes did not respond nor did they survive after 3 weeks of tissue culture, in contrast to normal small lymphocytes. This case is the 1st known adult patient with the Wiskott-Aldrich syndrome.