THE CELLULAR NATURE OF GENETIC SUSCEPTIBILITY TO A VIRUS

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Abstract
Using peritoneal macrophage cultures it was found that both PRI mice and their macro-phages in culture were susceptible to mouse hepatitis virus and that C3H mice and macrophages were resistant. All F1 macrophages and some back-cross cell cultures were susceptible. Segregation of susceptibility occurred in the first back-cross generation. Tests of 3 back-cross generations from susceptible mice showed about one-quarter of the mice to be susceptible either by direct test or test of their macrophages. A clear correlation between susceptibility in vivo and in vitro was established both in the test of the percentage segregation and in tests of individual back-cross mice. A small series of tests, however, indicated that 50% of the back-cross mice had the genetic capacity to transmit susceptibility. Resistant cells were con- verted into susceptible cells by ingestion of a relatively large particle containing a heat-stable substance. This susceptibility, although complete, was temporary.

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