A Contact Antitumor Activity of Bacillus natto on Solid Type Ehrlich Carcinoma Cells

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Abstract
The specificity of metabolic and hydrolytic activities of soil bacteria and Escherichia coli on benzoic acid derivatives, amino acids and acyl-amino acids and also on the acylase activity of ascites tumor cells was studied extensively. Based on these results, a search was made for some familiar bacteria which would have a high selective toxicity on human tumor cells. The 1st choice was the bacillus of "Natto" (fermented Japanese beans) which is a popular and cheap daily food for the Japanese. The contact antitumor effect of a strain (tentatively called KMD 1126) of Bacillus natto newly isolated from "Natto" is reported.

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