The pathogenesis of parvovirus‐induced cerebellar hypoplasia in the syrian hamster, Mesocricetus auratus. Fluorescent antibody, foliation, cytoarchitectonic, golgi and electron microscopic studies
- 9 October 1976
- journal article
- research article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 169 (4) , 481-521
- https://doi.org/10.1002/cne.901690405
Abstract
Cerebellar histogenesis was studied in hamsters infected at birth with a parvovirus, rat virus strain PRE 308. Cerebellar granule cell precursors in these animals were selectively infected and lysed in the external germinal layer before their migration to form the internal granular layer. The effects of the absence of granule cells on cerebellar development and especially on the development of the Purkinje cells and their dendrites were analyzed using fluorescent antibody, Golgi, conventional paraffin, and EM methods. This study represents the first Golgi and ultrastructural study of the pathogenesis of rat virus infections in the cerebellum.This publication has 49 references indexed in Scilit:
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