Assignment of the human tyrosine aminotransferase gene to chromosome 16
- 1 March 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 72 (3) , 225-228
- https://doi.org/10.1007/bf00291882
Abstract
The liver enzyme tyrosine aminotransferase (TAT; EC 2.6.1.5) catalyzes the rate-limiting step in the catabolic pathway of tyrosine. Deficiency in TAT enzyme activity underlies the autosomally inherited disorder tyrosinemia II (Richner-Hanhart syndrome). Using a human TAT cDNA clone as hybridization probe, we have determined the chromosomal location of the TAT structural gene by Southern blot analysis of DNAs from a series of human x rodent somatic cell hybrids. The results assign the TAT gene to human chromosome 16.This publication has 21 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Isolation, characterization and chromosomal mapping of the mouse tyrosine aminotransferase geneJournal of Molecular Biology, 1985
- Report of the committee on comparative mappingCytogenetic and Genome Research, 1985
- Report of the committee on the genetic constitution of chromosomes 13, 14, 15 and 16Cytogenetic and Genome Research, 1985
- Regulation of the synthesis of tyrosine aminotransferase: the relationship to mRNATATMolecular and Cellular Biochemistry, 1983
- Purification and properties of human liver tyrosine aminotransferaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1982
- Development of tyrosine aminotransferase and para-hydroxyphenylpyruvate dioxygenase activities in fetal and neonatal human liver.Journal of Clinical Investigation, 1982
- A simple, rapid, and sensitive DNA assay procedureAnalytical Biochemistry, 1980
- Genetic control of morphogenetic and biochemical differentiation: Lethal albino deletions in the mouseCell, 1979
- The Developmental Formation of Enzymes in Rat LiverPublished by Elsevier ,1970