Confinement and Controlled Release of Bisphosphonates on Ordered Mesoporous Silica-Based Materials
Top Cited Papers
- 1 June 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (25) , 8116-8117
- https://doi.org/10.1021/ja062286z
Abstract
Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering.Keywords
This publication has 6 references indexed in Scilit:
- Third-Generation Biomedical MaterialsScience, 2002
- Modeling and comparison of dissolution profilesEuropean Journal of Pharmaceutical Sciences, 2001
- A New Property of MCM-41: Drug Delivery SystemChemistry of Materials, 2000
- Existence of a Microporous Corona around the Mesopores of Silica-Based SBA-15 Materials Templated by Triblock CopolymersJournal of the American Chemical Society, 2000
- From Microporous to Mesoporous Molecular Sieve Materials and Their Use in CatalysisChemical Reviews, 1997
- Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanismNature, 1992