Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa
- 19 November 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 286 (5444) , 1561-1565
- https://doi.org/10.1126/science.286.5444.1561
Abstract
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA).Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.Keywords
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