Metabolism of C14-Ethanol by Surviving Rat Tissues

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Abstract
The rate of oxidation of ethanol by rat liver tissue in vitro is affected by the concn. when the surrounding medium is below 60 mg.%; from this concn. to 250 mg.% the rate of oxidation is constant. The relation of this finding to the possible involvement of more than one enzyme system was discussed. Of the tissues studied the kidney has the greatest ability to oxidize ethanol to CO2 and water, but the liver exceeds the kidney in its ability to convert ethanol to lipids. The lung can convert ethanol both to CO2 and to fatty acids. The diaphragm was able to oxidize ethanol only very slightly and was totally unable to convert it to lipids. The brain showed no ability to metabolize ethanol.