Rapid Effects of Hypoxia on the Cerebrospinal Fluid Levels of Adenosine and Related Metabolites in Newborn and One-Month-Old Piglets
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 59 (1) , 54-59
- https://doi.org/10.1159/000243322
Abstract
The effect of hypoxia on the levels of adenosine, inosine and hypoxanthine in the cerebrospinal fluid (CSF) was determined by HPLC in newborn (1- to 3-day-old, n = 6) and 1-month-old (n = 5) piglets. Serial CSF samples (q 60 s) were obtained from the cisterna magna during normoxia and a 5-min hypoxia test (PaO2 = 26.5 ± 2.9 Torr). In normoxia, newborns had a lower mean (± SEM) CSF concentration of adenosine (0.72 ± 0.17 vs. 2.60 ± 0.44 μM) and a higher concentration of hypoxanthine (4.88 ± 0.41 vs. 1.39 ± 0.60 μM) than the mature piglets (p < 0.05). In all animals, hypoxia induced an increase in CSF levels of adenosine and its metabolites between 2 and 4 min. However, peak adenosine concentrations were higher in mature (4.17 ± 1.41 μM) than in newborn (1.55 ± 0.29 μM) piglets (p < 0.05). These data might explain deficient vasodilator adaptation required for neonatal CBF regulation.Keywords
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