EXPERIMENTAL-INFECTION OF PIGS WITH A NEW PORCINE ENTERIC CORONAVIRUS, CV-777

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (2) , 219-223
Abstract
Cesarean-derived colostrum-deprived and conventionally reared pigs were orally inoculated with the coronavirus-like agent, CV 777, isolated from an outbreak of epizootic diarrhea in swine of all ages. Viral particles detected by EM in the feces and intestinal contents of inoculated pigs had the typical coronavirus morphology. This coronavirus-like agent is apparently different from the 2 known porcine coronaviruses, transmissible gastroenteritis virus and hemagglutinating encephalomyelitis virus. The experimental infection of pigs with this new agent resulted in vomiting, diarrhea and dehydration. This coronavirus-like agent replicated in the epithelial cells covering the small intestinal villi but, unlike transmissible gastroenteritis virus, it replicated in the epithelial cells covering the large intestinal villi.