MUTAGENIC POTENCY OF HETEROCYCLIC AMINES IN THE DROSOPHILA WING SPOT-TEST AND ITS CORRELATION TO CARCINOGENIC POTENCY
- 1 January 1985
- journal article
- research article
- Vol. 76 (6) , 468-473
Abstract
The Drosophila wing spot test is fast and sensitive for detecting somatic mutation and recombination. Nine heterocyclic amines, which had been identified as mutagenic constituents of cooked food by using the Salmonella/mammalian-microsome test system, were orally fed to larvae of the tester strain. All the compounds (Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2, IQ, MeIQ, MeIQx, A.alpha.C, MeA.alpha.C) showed mutagenicity in this system. The reported values of carcinogenic potency in the mouse assay for 7 of the 9 compounds showed an excellent correlation with mutagenic potency values obtained in the Drosophila assay, but not with those obtained in the Salmonella assay, indicating that the Drosophila short-term test is promising for quantitative prescreening of potential carcinogens.This publication has 4 references indexed in Scilit:
- Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extractCarcinogenesis: Integrative Cancer Research, 1984
- Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysatesCarcinogenesis: Integrative Cancer Research, 1984
- Somatic mutation and recombination test in Drosophila melanogasterEnvironmental Mutagenesis, 1984
- Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulinBiochemical and Biophysical Research Communications, 1978