Tropical Splenomegaly Syndrome in a Rwandan Kindred in Uganda
- 8 July 1972
- Vol. 3 (5818) , 79-82
- https://doi.org/10.1136/bmj.3.5818.79
Abstract
Twenty members of an immigrant Rwandan kindred were all found to have tropical splenomegaly syndrome compared with 29 out of 50 matched neighbour controls. Splenomegaly among the controls tended to cluster within families. IgM levels were significantly raised in the kindred compared with the control subjects without splenomegaly but were similar to those of neighbours with splenic enlargement. We advance a hypothesis that tropical splenomegaly syndrome results from the production of circulating immune complexes in individuals genetically predisposed to produce an IgM antibody response.Keywords
This publication has 23 references indexed in Scilit:
- Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups.1969
- ABSENCE OF SICKLE TRAIT IN PATIENTS WITH TROPICAL SPLENOMEGALY SYNDROMEThe Lancet, 1969
- Immune-Complex DiseaseNew England Journal of Medicine, 1969
- Spleen weights in Uganda with reference to malaria, migration and idiopathic tropical splenomegalyTransactions of the Royal Society of Tropical Medicine and Hygiene, 1969
- Idiopathic Tropical Splenomegaly Syndrome in IbadanBMJ, 1968
- MALARIAL ANTIBODIES AND AUTOANTIBODIES TO HEART AND OTHER TISSUES IN THE IMMIGRANT AND INDIGENOUS PEOPLES OF UGANDAThe Lancet, 1968
- The tropical splenomegaly syndromeTransactions of the Royal Society of Tropical Medicine and Hygiene, 1968
- SPLENOMEGALY IN NEW GUINEA1967
- TROPICAL SPLENOMEGALY IN NEW GUINEA1967
- IMMUNOHISTOLOGICAL AND SEROLOGICAL STUDIES IN ENDOMYOCARDIAL FIBROSISThe Lancet, 1966