X-inactivation pattern in the epididymis of sex-reversed mice heterozygous for testicular feminization
Open Access
- 1 August 1974
- journal article
- Published by The Company of Biologists in Development
- Vol. 32 (1) , 217-225
- https://doi.org/10.1242/dev.32.1.217
Abstract
Female mice heterozygous for testicular feminization were sex-reversed by means of the autosomal sex reversal mutation (Sxr). Due to X-inactivation, the blastemata for male sex organs in these animals are composed of a mixture of cells, carrying either the wildtype X chromosome or the X chromosome affected with Tfm in an active state. Thus, the two types of cells are sensitive to androgens or insensitive to androgens, respectively. This mosaic could be demonstrated in the epididymis on a cellular level. Segments of undifferentiated Tfm cells were found alternating with normally differentiated wild-type cells. The ultras truc tura] appearance of the mosaic is described.Keywords
This publication has 11 references indexed in Scilit:
- Modification of Expression of the Testicular feminization (Tfm) Gene of the Mouse by a “Controlling Element” GeneNature New Biology, 1973
- The ultrastructure of the principal cells and intraepithelial leucocytes in the initial segment of the rat epididymisThe Anatomical Record, 1973
- Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminizationJournal of Clinical Investigation, 1972
- X‐CHROMOSOME INACTIVATION AND DEVELOPMENTAL PATTERNS IN MAMMALSBiological Reviews, 1972
- Noninducible Phenotype exhibited by a Proportion of Female Mice Heterozygous for the X-Linked Testicular Feminization MutationNature New Biology, 1971
- Sex-reversed mice: XX and XO malesCytogenetic and Genome Research, 1971
- X-linked Gene for Testicular Feminization in the MouseNature, 1970
- X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod typeClinical Genetics, 1970
- Fine structure of the Wolffian duct and cytodifferentiation of the epididymis in fetal ratsCell and tissue research, 1969
- Gene Action in the X-chromosome of the Mouse (Mus musculus L.)Nature, 1961