Wnt/Frizzled Signaling in the Vasculature: New Angiogenic Factors in Sight
- 1 June 2006
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 21 (3) , 181-188
- https://doi.org/10.1152/physiol.00058.2005
Abstract
Wnt growth factors function via Frizzled receptors to affect cellular proliferation, differentiation, apoptosis, and migration. Wnt/Frizzled signaling is now linked to human hereditary disorders with retinal vascular defects, implicating Wnts as angiogenic factors. Here, we discuss Wnts and a novel Frizzled ligand, Norrin, in physiological and pathological angiogenesis.Keywords
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