Antitumor activity of 4-nitropyridazine 1-oxides and related compounds for AH-13.
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (3) , 504-506
- https://doi.org/10.1248/cpb.25.504
Abstract
Antitumor activity of 4-nitropyridazine-1-oxides and related compounds was tested with the rat ascites hepatoma AH-13 system. Among these nitro compounds, 3,6-dimethoxy-4-nitropyridazine-1-oxide (III) and 4-nitrocinnoline-1-oxide (XIII) were the most effective. 4-Nitropyridazine-1-oxide (I), 3,6-dimethyl-4-nitropyridazine-1-oxide (II) and 3-alkoxy-4-nitro-6-chloropyridazine-1-oxides (VI, VII) were effective to some extent.This publication has 1 reference indexed in Scilit:
- Syntheses of 1-alkoxy-3,6-dimethyl-5-nitro-4(1H)-pyridazionenses and related compounds.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975