Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
Open Access
- 31 March 2008
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 181 (1) , 9-13
- https://doi.org/10.1083/jcb.200802155
Abstract
Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.Keywords
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