Effect of chemical stimulation of the septal area on motivation.

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Abstract
Cholinergic stimulation of the medical septal area of rats (a) elicited drinking in sated Ss and increased the water consumption of thirsty Ss; (b) depressed food intake of hungry Ss; (c) impaired the performance of previously ac-quired avoidance behavior and prevented toe acquisition of new avoidance responses. Applications of a cholinergic blocking agent to the septal area: (a) reduced the water consumption of thirsty Ss; (b) improved the performance of a previously acquired avoidance response. Adrenergic stimulation of the septal area failed to affect food or water intake but produced a reliable improvement of avoidance behavior.