Immunoprevention of x-ray-induced leukemias in the C57BL mouse.

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Abstract
An attempt to prevent irradiation induced thymic lymphomas in C57BL mice was made by inducing active immunity to endogenous type C virus with inactivated Rauscher murine leukemia virus (MuLV), inactivated Gross MuLV or by transferring passive immunity to endogenous type C virus with goat anti-Gross MuLV Ig[immunoglobulin]G. Control groups received the following immunogen or treatment: inactivated simian sarcoma virus, complete Freund''s adjuvant, normal goat IgG and diluent, in irradiated and nonirradiated C57BL mice. Active immunity to the 70,000 MW glycoprotein AKR-gp70 by immunization with Rauscher MuLV and passive immunity to AKR-gp70 by passive transfer of goat anti-Gross MuLV IgG was measurable throughout some of the latent period of tumor development. In these 2 groups a significant reduction in tumor incidence was observed, as compared to the other experimental and control groups. The present findings support the concept of a type C virus etiology of irradiation induced leukemias and demonstrate the applicability of immunologic techniques directed against the endogenous type C virus in the prevention of this disease.