Effects of Diethylstilbestrol, 17 Beta Estradiol, and Progesterone on Plasma Fibrinogen Levels in Rats Submitted to Tissue Injury (Laparotomy)

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Abstract
Participation of estrogens (17-.beta. estradiol, diethylstilbestrol) and progesterone in the increase of plasma fibrinogen levels in female rats submitted to tissue injury (laparotomy) was studied [as it was found that the use of oral contraceptives has a greater risk of thromboembolic disease especially after surgery]. Ovariectomy avoided the increase of fibrinogen observed in laparotomized rats, while the administration of 17.beta.- estradiol or diethylstilbestrol to laparotomized-ovariectomized rats increased fibrinogen to levels similar to those observed in the group of laparotomized rats without other treatment. Progesterone inhibited the increase of fibrinogen which is typical of laparotomy in both groups: one of laparotomized rats and the other of laparotomized rats injected with estrogens. Neither estrogens nor progesterone modify plasma fibrnogen levels in uninjured rats. Estrogens might participate in the fibrinogen increase observed after tissue injury in female rats, and on the contrary, the administration of progesterone would render that increase null.

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