THE H-2 PHENOTYPES OF RANDOM-BRED SWISS-WEBSTER MICE

Publisher Website
Google Scholar
Abstract
Hemagglu-tinating sera, verified as reacting normally with known H-2 antigens, were used to determine the H-2 antigens of Swiss-Webster mice that had been random-bred for 25 years. Evidence for the existence of previously undescribed H-2 phenotypes was found. The pattern of occurrence of H-2 antigens did not conform with combinations of currently known H-2 alleles. The observations indicate the probable existence of new H-2 genes and combinations of them. New H-2 antigens may be expected. An experimental demonstration of one such antigen is given. On the basis of these observations the H-2 alleles that have been demonstrated by studies of inbred strains of mice appear selected simplifications of a major histocompatibility locus or groups of loci.

This publication has 2 references indexed in Scilit: