Decreased resistance to infection in exercised mice exposed to NO2and O3

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Abstract
A mechanized wheel was constructed for use in evaluating the interaction of exercise and gaseous pollutants such as O3 and NO2. Immediately after pollutant exposure, exercised and nonexercised female mice (CD-1) were combined with controls, challenged with an aerosol of viable Streptococcus pyogenes (group C) and observed over 15 days for mortality rates. Exposure to O3 at 196 .mu.g/m3 (0.1 ppm) or 590 .mu.g/m3 (0.3 ppm) while exercising yielded mortality rates that were significantly higher than those observed in the O3 groups that were not exercised. With exposure to NO2 at 5640 .mu.g/m3 (3 ppm), exercise produced a significant increase in mortality rate compared to other treatment groups. Exercise can affect the mortality observed in this model system. Safe exposure levels of pollutants, as a function of the activity level of the exposed population, should be established.

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