The Relative Weight of the Gray and White Matter of the Normal Human Brain

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Abstract
The relative proportion of gray and white matter of the normal human brain was determined to be approximately 60% and 40% respectively in the cerebral hemispheres and in the brain as a whole, by calculations based on the water content of these tissues. With this technique, the value for gray matter is an approximate measure of a myelin-free abstraction, rather than of the actual anatomic gray structures; e.g. structures such as the globus pallidus which contain many myelinated fibers would act as a mixture of tissues, and would not be included entirely with the gray matter. This abstraction may have pathological significance.

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