Kallmann syndrome gene on the X and Y chromosomes: implications for evolutionary divergence of human sex chromosomes
- 1 December 1992
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 2 (4) , 311-314
- https://doi.org/10.1038/ng1292-311
Abstract
The recently identified gene for X-linked Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) has a closely related homologue on the Y chromosome. The X and Y copies of this gene are located in a large region of X/Y homology, on Xp22.3 and Yq11.2, respectively. Comparison of the structure of the X-linked Kallmann syndrome gene and its Y homologue shed light on the evolutionary history of this region of the human sex chromosomes. Our data show that the Y homologue is not functional. Comparative analysis of X/Y sequence identity at several loci on Xp22.3 and Yq11.2 suggests that the homology between these two regions is the result of a complex series of events which occurred in the recent evolution of sex chromosomesKeywords
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