Shear Degradation of Fibrinogen in the Circulation
- 23 October 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 170 (3956) , 466-468
- https://doi.org/10.1126/science.170.3956.466
Abstract
Plasma fibrinogen in vitro suffers a loss in clottability due to shearing. From calculation of the mass average shear to which plasma is subjected in the circulation, it is estimated that the half-life of fibrinogen is 4 days. This is in excellent agreement with reports that the half-life of fibrinogen in the circulatory system is 4 to 5 days. Hence shearing may be the mechanism for fibrinogen degradation in the circulatory system.Keywords
This publication has 2 references indexed in Scilit:
- Enzyme inactivation with shearingBiotechnology & Bioengineering, 1970
- Fibrinogen from Human Plasma: Preparation by Precipitation with Heavy-Metal Coordination ComplexScience, 1967