Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HC1 in man
- 9 October 1996
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 42 (4) , 510-512
- https://doi.org/10.1111/j.1365-2125.1996.tb00017.x
Abstract
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.Keywords
This publication has 7 references indexed in Scilit:
- Kidney Function and Age Are Both Predictors of Pharmacokinetics of MetforminThe Journal of Clinical Pharmacology, 1995
- 11 Treatment—metforminBailliere's Clinical Endocrinology and Metabolism, 1988
- Metformin in the digestive tractDiabetes Research and Clinical Practice, 1988
- Metformin kinetics in healthy subjects and in patients with diabetes mellitus.British Journal of Clinical Pharmacology, 1981
- Pharmacokinetics of metformin after intravenous and oral administration to manEuropean Journal of Clinical Pharmacology, 1979
- Disposition of metformin (N,N‐dimethylbiguanide) in manClinical Pharmacology & Therapeutics, 1978