Comparison of Oxytetracycline and Chlortetracycline in the Treatment of Non-Gonococcal Urethritis

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Abstract
Previous study of the efficacy of Terra-mycin, Aureomycin, chloramphenicol, streptomycin, penicillin, and the sulfonamides in the treatment of non-gonococcal urethritis showed the superiority of Terramycin and Aureomycin. Failure rates were higher in previously treated than in previously untreated cases. Failure rates with Terramycin were shown to vary according to dose given. When previously untreated patients given 5-6 g Aureomycin or Terramycin were compared, Terramycin was apparently the more efficacious, but the numbers involved were too small for a valid statistical comparison. The series of previously untreated patients with non-gonococcal urethritis given 5-6 g Aureomycin or Terramycin was enlarged to 107 with Aureomycin and 65 with Terramycin. All relapses and re-infections occurring within 3 post-treatment months were grouped as failures, and incidents occurring after a symptom-free period of 3 months were considered to be re-infections and excluded. The cumulative failure rates at 3 months for the 2 drugs are the same.

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