Optically active organometallic compounds. Part I. Absolute configuration of (–)-1,1′-dimethylferrocene-3-carboxylic acid by X-ray analysis of its quinidine salt
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc. A
- p. 365-373
- https://doi.org/10.1039/j19670000365
Abstract
The quinidine salt of (–)-1,1′-dimethylferrocene-3-carboxylic acid crystallises from aqueous ethanol as a monohydrate: the crystals are orthorhombic, space group P212121, with four units of C33H40FeN2O5 in a cell of dimensions a= 15·44, b= 28·12, c= 6·79 Å. The crystal structure was elucidated by the heavy-atom method, and Fourier and least-squares methods were employed in the determination of the atomic parameters. The analysis defines the absolute configuration of (–)-1,1′-dimethylferrocene-3-carboxylic acid and confirms the accepted absolute stereochemistry of the alkaloid quinidine. The molecules are held together in the crystal by a system of hydrogen bonds.Keywords
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