Reactivity of monoclonal antibody OKM5 with sebaceous carcinoma
- 1 October 1991
- journal article
- case report
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 18 (5) , 323-327
- https://doi.org/10.1111/j.1600-0560.1991.tb01543.x
Abstract
Two cases of sebaceous carcinoma (SC), as well as epithelial tumours, melanoma, and lymphoma, were examined using immunoperoxidase and a panel of monoclonal antibodies on cryostat sections. The results showed that, whereas all SC cells in both cases reacted strongly with monoclonal antibody OKM5, other tumour cells (except juvenile xanthogranuloma cells) did not. The pagetoid cells within the epidermis of SC also reacted with OKM5 antibody. Although the nature of the phenomenon merits further study, this reactivity, or cross-reactivity, might possibly aid diagnosis of SC.Keywords
This publication has 6 references indexed in Scilit:
- Occurrence of Langerhans cells and expression of class II antigens on keratinocytes in malignant and benign epithelial tumors of the skin: An immunohistopathologic study with monoclonal antibodiesJournal of the American Academy of Dermatology, 1989
- Distribution patterns of the OKM 5 antigen in normal and diseased human epidermisJournal of Cutaneous Pathology, 1989
- Eyelid Tumors: Clinical Diagnosis and Surgical TreatmentAnnals of Plastic Surgery, 1988
- Expression of OKM5 Antigen on Epidermal Cells in Mycosis Fungoides Plaque StageJournal of Investigative Dermatology, 1988
- Sebaceous Carcinoma of Meibomian Gland Origin: The Diagnostic Importance of Pagetoid Spread of Neoplastic CellsAmerican Journal of Clinical Pathology, 1980
- Present Status of Meibomian Gland CarcinomaArchives of Ophthalmology (1950), 1965