CHOLINESTERASE NEWFOUNDLAND - A NEW SUCCINYLCHOLINE-SENSITIVE VARIANT OF CHOLINESTERASE AT LOCUS-1

  • 1 January 1981
    • journal article
    • research article
    • Vol. 33  (3) , 366-374
Abstract
A family from Newfoundland [Canada] had a new rare variant for plasma cholinesterase recognized by a high-percentage inhibition by dibucaine (DN), particularly when succinyldithiocholine was used as substrate (DNSDTC) but somewhat high when benzoylcholine was substrate (DNBZCH). The variant is evidently determined by an allele of the usual and atypical alleles at locus 1 and the new allele is designated CHEl*NFLD. The proband who was heterozygous for the Newfoundland and atypical alleles showed sensitivity to succinylcholine. Cholinesterase Newfoundland (NFLD) apparently has a reduced affinity for succinylcholine. Samples selected for high DN with benzoylcholine from 200 Canadian Caucasians and 70 Newfoundlanders did not have the variant and the remainder of the samples probably did not have the variant.