Possible Relations of Hypoglycaemia Induced by Mono-amine Oxidase Inhibition and Angina Pectoris.

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Abstract
The mechanism of hypo-glycemia induced by mono-amine oxidase inhibition and its effect on the symptoms of angina pectoris were investigated. An oral glucose-galactose solution did not effect the ratio of blood glucose to total blood sugar (Glucose Index, GI) in 15 normal subjects and 15 untreated patients. Comparison of the results after ganglion blockade with mecamyl-amine showed a transient fall in the GI, probably due to hypoglycemic insensitivity. Mono-amine oxidase inhibition by Iproniazid or nialamide reduced the GI throughout the carbohydrate tolerance test in some patients, possible by an interference with hepatic glycogenolysis. Of 12 patients with angina pectoris treated by mono-amine oxidase inhibitors 8 improved, and this correlated roughly with a reduction of the GI. This suggests that changes in the primary sources of energy available to the heart muscle may modify the symptoms of angina pectoris.

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