Sulfasalazine

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Abstract
A PREVALENT view of rheumatoid arthritis in the late 1930's was that the disease had both infectious and inflammatory components, and thus it seemed reasonable that a therapeutic agent might be designed that combined in a single molecule both antibacterial and anti-inflammatory activity. One of the drugs introduced as a result of this reasoning was sulfasalazine (Fig. 1), which combined the recently introduced antibacterial drug sulfapyridine with the anti-inflammatory agent salicylate.1 Although time has failed to justify the original hopes for a drug active against rheumatoid arthritis, sulfasalazine has been demonstrated to be useful in the therapy and prophylaxis of . . .