Alteration in Pulsatile Release of LH in Aging Female Rats

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Abstract
Amplitude of pulsatile release of LH [luteinizing hormone, lutropin] was examined in ovariectomized rats of ages 3-4, 9-11 and 17-18 mo., serially bled via chronic jugular catheters. At the time of ovariectomy, rats showed normally cycling (NC), irregularly cycling (IC) or constant estrus (CE) ovarian activity. Amplitude of pulsatile LH release was significantly reduced in CE rats as compared to all other groups. LH pulse amplitude appeared to be more closely associated with reproductive state at the time of ovariectomy than with the age of the animal. LH pulse amplitude was greatest in NC rats, intermediate in IC rats and lowest in CE rats, regardless of age. A common, central mechanism may be responsible for both the changes in pulsatile LH release which accompany aging in the rat.

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