Studies on Ukinary Phenolic Compounds in Man VI. Excretion of p-Hydroxy-Mandelic Acid by Man and Dog

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Abstract
By screening urine for phenolic acids from different mammals, we found an exceptionally large amount of a phenolic acid which was identified as p-hydroxy-mandelic acid [HMA] in dogs. Per mg of creatinine the HMA excretion was 30[long dash]60 times higher than in man. The excretion of p-hydroxy-mandelic acid is, however, very constant both in man and dog, when they do not eat oranges. In dogs the p-hydroxy-phenyl-lactic acid, p-hydroxy-phenyl-benzoic acid and 3-methoxy-4-hydroxy-phenyl-lactic acids were also elevated compared to man. The excretion of vanillyl-mandelic acid, however, was only approximately 1/10 of normal amounts in man. Since we were unable to find p-hydroxy-phenyl-glycol, and since the p-hydroxy-mandelic acid did not respond to monoamine oxydase inhibitor, antibiotics or disulfiram, and since it is levorotatory, an unknown metabolic pathway is suggested. This unknown pathway, which is relatively small in man, seems to be very prominent in dog.

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