No evidence for product inhibition of the renin-angiotensinogen reaction in the rat.
- 1 October 1977
- journal article
- abstracts
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 41 (4) , 49-54
- https://doi.org/10.1161/01.res.41.4.49
Abstract
The influence of the product of the renin-angiotensinogen reaction, the des-angiotensin I-substrate (des-AI-substrate) on the renin-angiotensinogen reaction has been studied. Des-AI-substrate was prepared from purified rat angiotensinogen by reaction with immobilized renin. The des-AI-substrate had no inhibitory effect on the reaction of partially purified rat renin with rat angiotensinogen at concentrations corresponding to 0.225 or 0.45 micrometer angiotensinogen.Keywords
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