Biologically Active Acylglycerides from the Berries of Saw-Palmetto (Serenoa repens)
- 1 April 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (4) , 417-418
- https://doi.org/10.1021/np960552o
Abstract
Brine shrimp lethality-directed fractionation of the 95% EtOH extract of the powdered, dried berries of Serenoa repens (Bart.) Small (saw-palmetto) (Palmae) led to the isolation of two monoacylglycerides, 1-monolaurin (1) and 1-monomyristin (2). Compounds 1 and 2 showed moderate biological activities in the brine shrimp lethality test and against renal (A-498) and pancreatic (PACA-2) human tumor cells; borderline cytotoxicity was exhibited against human prostatic (PC-3) cells. The fruits and extracts of saw-palmetto are taken orally as an herbal medicine to prevent prostatic hyperplasias.Keywords
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