PCILO and CD. Conformational study of sulpiride, a dopamine antagonist
- 4 November 1981
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 64 (7) , 2183-2188
- https://doi.org/10.1002/hlca.19810640724
Abstract
The conformational behaviour of sulpiride has been investigated by the quantum mechanical PCILO method and by CD. measurements. The results indicate the predominance of a folded, intramolecularly H‐bonded conformer, with extended conformers being only slightly less stable. The pharmacological relevance of these results is briefly discussed.Keywords
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